Backbone chemical shift assignments of human 14-3-3σ
نویسندگان
چکیده
منابع مشابه
14-3-3σ, the double-edged sword of human cancers
14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. 14-3-3σ has been considered as a tumor suppressor with reduced expression in some human cancers while its increased expression causes resistance to anticancer agents and radiation that cause DNA damages. The increased expression of 14-3-3σ may also predict poor prognosis in some hum...
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Loss of 14-3-3σ expression through DNA methylation has been associated with carcinogenesis and the prognosis for various cancer types. Detection of methylation of the gene in serum may be useful for diagnostic utility. The present study aimed to investigate the correlation between 14-3-3σ methylation level in 36 paired tumor tissues of non-small cell lung cancer (NSCLC) and matched serum using ...
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The homeobox gene (Hoxa13) codes for a transcription factor protein that binds to AT-rich DNA sequences and controls expression of many important proteins during embryonic morphogenesis. We report complete backbone NMR chemical shift assignments of mouse Hoxa13 DNA binding domain bound to an 11-residue DNA duplex (BMRB no. 16577).
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In human epidermal keratinocytes, replicative senescence, is determined by a progressive decline of clonogenic and dividing cells. Its timing is controlled by clonal evolution, that is, by the continuous transition from stem cells to transient amplifying cells. We now report that downregulation of 14-3-3sigma, which is specifically expressed in human stratified epithelia, prevents keratinocyte ...
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193 Received March 14, 2013; revised and accepted October 12, 2013. Published online November 7, 2013; doi: 10.1620/tjem.231.193. Correspondence: Satoru Nagase, M.D., Ph.D., Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. e-mail: [email protected] Decreased Expression of 14-3-3σ Is Predicti...
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ژورنال
عنوان ژورنال: Biomolecular NMR Assignments
سال: 2018
ISSN: 1874-2718,1874-270X
DOI: 10.1007/s12104-018-9860-1